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Related Experiment Videos

Ultrastructural observations in disseminated candidiasis.

R L Myerowitz

    Archives of Pathology & Laboratory Medicine
    |October 1, 1978
    PubMed
    Summary

    Disseminated candidiasis involves Candida yeast cells invading organs like the spleen and liver. These fungi may promote blood clotting and possess a host-derived outer coat.

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    Area of Science:

    • Medical Mycology
    • Cellular Biology
    • Pathology

    Background:

    • Disseminated candidiasis is a serious invasive fungal infection.
    • Understanding the host-parasite interaction is crucial for treatment.
    • Candida species are common opportunistic pathogens.

    Purpose of the Study:

    • To investigate the cellular mechanisms of host-parasite interactions in disseminated candidiasis.
    • To examine the ultrastructural features of Candida cells within infected host tissues.

    Main Methods:

    • Electron microscopy was used to examine infected tissues from four patients.
    • Ultrastructural analysis of Candida blastospores and pseudohyphae in various organs.
    • Comparison of in vitro cultured Candida with in vivo organisms.

    Main Results:

    • Candida blastospores and pseudohyphae invaded parenchymal cells in multiple organs (spleen, liver, kidney, etc.).
    • Candida cells remained intact within degenerating host cells.
    • Extracellular fungi were associated with fibrin and thrombi, suggesting procoagulant activity.
    • The outer yeast cell coat had a host-derived component.

    Conclusions:

    • Candida actively invades host tissues at a cellular level.
    • Candida may possess mechanisms to evade host defenses and promote thrombosis.
    • The outer coat's composition suggests interaction with host proteins.

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