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Maturation of renal organic acid transport: substrate stimulation by penicillin
Science (New York, N.Y.)
|August 29, 1969
Insights
Renal p-aminohippurate transport matures rapidly in young rabbits. Continued penicillin exposure during development enhances this maturation process but doesn't alter the peak transport rate.
Area of Science:
- Nephrology
- Developmental Biology
- Pharmacology
Background:
- Renal transport systems undergo significant development postnatally.
- P-aminohippurate (PAH) transport is a key indicator of renal function.
- Understanding developmental regulation of renal transporters is crucial for pediatric nephrology.
Purpose of the Study:
- To investigate the developmental pattern of renal p-aminohippurate (PAH) transport in rabbits.
- To determine the effect of penicillin exposure on the maturation of the PAH transport system.
- To elucidate the role of substrate availability during development.
Main Methods:
- Studied renal PAH transport rates in rabbits from birth to adulthood.
- Administered penicillin to pregnant does and newborn rabbits.
- Quantified PAH transport capacity at different developmental stages.
Main Results:
- PAH transport increased significantly from birth to 4 weeks, then declined to adult levels.
- Penicillin administration stimulated the developing PAH transport system.
- Peak PAH transport at 4 weeks was not elevated by penicillin exposure.
Conclusions:
- Renal PAH transport exhibits a distinct developmental trajectory in rabbits.
- Early-life penicillin exposure can enhance the rate of maturation of the renal transport system.
- The peak functional capacity of the transporter may be developmentally programmed irrespective of substrate availability.
Abstract:
Renal p-aminohippurate transport in rabbits increased rapidly from birth to 4 weeks of age and then declined to that observed in adults. Penicillin administration to pregnant does or newborn rabbits stimulated the developing transport system, but did not increase the peak observed at 4 weeks. Therefore the continued presence of substrate (penicillin) during development significantly enhances the rate of maturation.