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Related Experiment Videos

Esophageal motor function in Graves' disease.

H Meshkinpour, M A Afrasiabi, L J Valenta

    Digestive Diseases and Sciences
    |February 1, 1979
    PubMed
    Summary
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    Graves' disease significantly speeds up esophageal contractions. Thyroid hormones may influence esophageal motor function, as this effect reversed when patients became euthyroid after treatment.

    Area of Science:

    • Gastroenterology
    • Endocrinology
    • Physiology

    Background:

    • Graves' disease is an autoimmune disorder causing hyperthyroidism.
    • Thyroid hormones are known to affect various bodily functions, but their impact on esophageal motility is less understood.

    Purpose of the Study:

    • To investigate esophageal motor function in patients with untreated Graves' disease.
    • To determine the role of thyroid hormones in regulating esophageal peristalsis.

    Main Methods:

    • Esophageal manometry using a triple-lumen assembly was performed on 10 patients with Graves' disease and 15 healthy controls.
    • Measurements included resting sphincter pressures, peristaltic amplitude, duration, velocity, and contraction patterns.
    • 5 patients were restudied after treatment with radioactive iodine (131I) to assess changes after achieving euthyroid status.

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    Main Results:

    • Patients with Graves' disease exhibited significantly increased velocity of esophageal peristaltic contractions compared to controls.
    • No significant differences were observed in peristaltic amplitude or duration.
    • Following treatment and normalization of thyroid hormone levels, the increased contraction velocity in patients returned to levels similar to controls.

    Conclusions:

    • Thyrotoxicosis, a state of excess thyroid hormone, accelerates the propagation velocity of esophageal contractions.
    • Thyroid hormones appear to play a physiological role in the regulation of esophageal motor function.