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Absolute bioavailability of digoxin tablets.

T Beveridge, E Nüesch, E E Ohnhaus

    Arzneimittel-Forschung
    |January 1, 1978
    PubMed
    Summary
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    This study determined the oral bioavailability of digoxin tablets in healthy males. Digoxin tablets demonstrated 78% absolute bioavailability compared to intravenous injection.

    Area of Science:

    • Pharmacokinetics
    • Drug Absorption
    • Clinical Pharmacology

    Background:

    • Digoxin is a cardiac glycoside used to treat heart failure and arrhythmias.
    • Understanding digoxin's oral bioavailability is crucial for accurate dosing and therapeutic efficacy.

    Purpose of the Study:

    • To quantify the absolute bioavailability of Sandoz digoxin tablets.
    • To compare oral versus intravenous administration of digoxin.

    Main Methods:

    • Randomized, cross-over study in 10 healthy male volunteers.
    • Oral and intravenous administration of 0.5 mg digoxin.
    • Plasma digoxin concentrations and urinary excretion measured via radioimmunoassay.

    Main Results:

    • Absolute bioavailability of digoxin tablets was calculated using four methods.

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  • The mean of two extrapolated values for absolute bioavailability was 78%.

    • Conclusions:

    • Sandoz digoxin tablets exhibit 78% absolute bioavailability.
    • This finding is important for clinical use and therapeutic drug monitoring.