Related Experiment Videos
[Enteral absorption of sulfasomidine depending on age (author's transl)]
Insights
Sulfasomidine absorption is complete in newborns and older children, but the rate of absorption is slower in newborns. This age-dependent difference impacts drug concentration timelines.
Area of Science:
- Pharmacokinetics
- Pediatric Pharmacology
- Drug Absorption
Context:
- Sulfonamides are crucial antibiotics, but their absorption can vary with age.
- Understanding pediatric drug absorption is vital for safe and effective dosing.
Purpose:
- To determine the completeness and rate of sulfasomidine absorption in newborns, infants, and older children.
- To investigate age-dependent differences in sulfasomidine intestinal absorption kinetics.
Summary:
- Sulfasomidine (6-(sulfanilamido)-2,4-dimethyl-pyrimidine) was administered intravenously and orally at 25 mg/kg to 29 newborns, 8 infants, and 9 older children.
- Complete absorption was observed in both newborns (95.7%) and older children (94.4%).
- The rate of absorption, modeled using the Bateman function, showed a significantly lower invasion rate constant (k1) in newborns compared to older children, with a prolonged time to maximum serum concentration (tmax).
Impact:
- Findings highlight significant age-dependent variations in sulfasomidine absorption rates.
- Results suggest potential implications for optimizing antibiotic dosing strategies in pediatric populations.
- This research contributes to the understanding of neonatal pharmacokinetics and safe sulfonamide use.
Abstract:
After intravenous and oral application of 25 mg 6-(sulfanilamido)-2,4-dimethyl-pyrimidine (sulfasomidin)/kg body-weight to 29 newborns, 8 infants and 9 older children the completeness and rate of absorption were determined. Sulfasomidine was completely absorbed in newborns (mean value 95.7%) as well as in older children (mean value 94.4%). Concerning the rate of absorption there were age-dependent differences. Using the Bateman function for the kinetic model of intestinal absorption the rate constant of invasion k1 was significantly lower in the first week of life compared to that in older children. In agreement with these data the time tmax of the maximum serum concentration was significantly prolonged in newborns compared to that of older children.