Related Experiment Video

Updated: Aug 10, 2026

Isolation of Double Negative αβ T Cells from the Kidney
06:56

Isolation of Double Negative αβ T Cells from the Kidney

Published on: May 16, 2014

Inhibition of lymphocyte blastogenesis by plasma of patients with minimal-change nephrotic syndrome

A V Moorthy, S W Zimmerman, P M Burkholder

    Lancet (London, England)
    |May 29, 1976
    PubMed

    Plasma from 7 patients with minimal-change nephrotic syndrome (M.C.N.S.) (lipoid nephrosis) confirmed by renal biopsy inhibited the blastogenic response of lymphocytes to the mitogen phytohaemagglutinin (P.H.A.) and to allogeneic lymphocytes in mixed lymphocyte culture. Plasma from 14 patients with nephrotic syndrome due to other glomerular diseases did not have this effect. 5 of the 7 patients with M.C.N.S. achieved remission; 4 with prednisone and 1 spontaneously. While in remission, plasma from these 5 patients no longer inhibited the response of lymphocytes to P.H.A. These findings suggest a pathogenic relation between M.C.N.S. and cell-mediated immunity.

    More Related Videos

    Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow08:01

    Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow

    Published on: November 4, 2016

    Rapid Quantification of Mitogen-induced Blastogenesis in T Lymphocytes for Identifying Immunomodulatory Drugs08:13

    Rapid Quantification of Mitogen-induced Blastogenesis in T Lymphocytes for Identifying Immunomodulatory Drugs

    Published on: December 27, 2016

    Related Concept Videos

    Nephrotic Syndrome II : Assessment and Medical Management01:26

    Nephrotic Syndrome II : Assessment and Medical Management

    IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...