Comparison of bioavailability of two dipyridamole formulations

The experiment carried out on 6 volunteers shows a better bioavailability of a 75 mg single oral dose of Persantin (Boehringer) than of the same dose of Curantyl (Germed). The difference is due to the manner in which the dragées are manufactured: the bioavailability of both preparations was the same when the dragées were pulverized before oral administration.