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Alkaline phosphatase isoenzyme patterns in hyperthyroidism.

D S Cooper, M M Kaplan, E C Ridgway

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    |February 1, 1979
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    Hyperthyroid patients often show elevated serum alkaline phosphatase (ALP) activity. Treatment can paradoxically increase ALP, particularly bone ALP, as thyroid hormone levels normalize.

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    Area of Science:

    • Endocrinology
    • Biochemistry

    Background:

    • Hyperthyroidism is associated with altered metabolic processes.
    • Serum alkaline phosphatase (ALP) levels can be affected by thyroid status.

    Purpose of the Study:

    • To investigate the relationship between serum alkaline phosphatase activity and thyroid hormone levels in hyperthyroid patients.
    • To analyze changes in ALP isoenzyme patterns during hyperthyroid treatment.

    Main Methods:

    • Serum alkaline phosphatase (ALP) activity and isoenzyme patterns were analyzed in 36 hyperthyroid patients.
    • Measurements were taken before, during, and after treatment.
    • Thyroid hormone levels (T4, T3) were monitored.
    • Polyacrylamide gel electrophoresis was used for isoenzyme analysis.

    Main Results:

    • Fifteen of 36 hyperthyroid patients exhibited elevated serum ALP.
    • During treatment, serum ALP levels increased as thyroxine (T4) levels decreased.
    • Bone-specific ALP increased significantly during treatment, correlating with declining T4.
    • Thyroid tissue from Graves' disease patients showed low ALP activity and a distinct isoenzyme pattern.

    Conclusions:

    • Elevated serum alkaline phosphatase, particularly bone ALP, is a common finding in treated hyperthyroidism.
    • Changes in ALP isoenzymes during treatment suggest a complex interplay between thyroid hormones and bone metabolism.
    • The observed ALP changes are distinct from intrinsic thyroid gland ALP activity.