Absorption of nutrients in lactase deficiency

Area of Science:

• Gastroenterology
• Human Nutrition

Background:

• Primary lactase deficiency is a common condition.
• Lactose malabsorption can affect nutrient absorption from milk.

Purpose of the Study:

• To investigate the impact of lactose malabsorption on the absorption of milk nutrients in adults with primary lactase deficiency.
• To compare nutrient absorption in lactase-deficient individuals versus healthy controls.

Main Methods:

• Ileal perfusion technique used in four healthy controls and four lactase-deficient subjects.
• Test meals included whole milk and lactose-hydrolyzed milk.
• Quantification of nutrient and marker (polyethylene glycol, PEG 4000) arrival in the ileum.

Main Results:

• Lactase-deficient subjects showed increased ileal fluid and nutrient recovery after whole milk compared to controls or after hydrolyzed milk.
• Greater quantities of protein, calcium, magnesium, and phosphorus were recovered in lactase-deficient subjects after whole milk.
• Marked lactose malabsorption (35-50%) was observed in two deficient subjects.

Conclusions:

• While lactose malabsorption occurs in primary lactase deficiency, its overall nutritional impact on adults appears minimal.
• Further research may be needed to fully understand long-term consequences.