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Related Experiment Videos

Abnormal blood viscosity in Raynaud's phenomenon.

K B Goyle, J A Dormandy

    Lancet (London, England)
    |June 19, 1976
    PubMed
    Summary

    Raynaud

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    Area of Science:

    • Rheology
    • Vascular Biology
    • Medical Science

    Background:

    • Raynaud's phenomenon is characterized by cold-induced attacks.
    • The precise etiology of Raynaud's remains undetermined.
    • Understanding blood flow alterations in response to temperature is crucial.

    Purpose of the Study:

    • To investigate the role of blood viscosity in Raynaud's phenomenon.
    • To compare blood viscosity in patients versus healthy controls under varying temperatures.
    • To explore potential causative factors related to blood rheology.

    Main Methods:

    • Blood viscosity measurements were conducted on ten Raynaud's patients and ten controls.
    • Viscosity was assessed at two temperatures: 27°C (cold) and 37°C (body temperature).
    • Low shear-rate (0.77 s⁻¹) measurements were utilized.

    Main Results:

    • Patients exhibited significantly higher blood viscosity at 27°C compared to controls (p < 0.05).
    • Elevated blood viscosity was observed at lower temperatures in Raynaud's patients.
    • Increased yield stress was also noted in the blood of patients.

    Conclusions:

    • Abnormal increases in blood viscosity and yield stress at low temperatures may contribute to Raynaud's phenomenon.
    • Cold-induced rheological changes in blood are implicated in the condition's pathophysiology.
    • This study suggests a potential link between blood rheology and Raynaud's attacks.

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