L-dopa induced dyskinesias in asymmetrical parkinsonism

Four patients with predominantly unilateral Parkinsonism are reported in whom involuntary movements in the affected limbs developed while on levodopa. Based on the known pathological and biochemical abnormalities underlying Parkinson's disease, it is suggested that these observations support the concept of denervation supersensitivity as the pathogenetic mechanism in the development of levodopa dyskinesias.