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Anticomplementary activity in diffuse and nodular goiters.

U Feldt-Rasmussen, K Bech, J Date

    Acta Pathologica Et Microbiologica Scandinavica. Section C, Immunology
    |December 1, 1979
    PubMed
    Summary
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    Anticomplementary activity was found in thyroid disease patients, particularly those with Graves' disease. This activity correlated with thyroid stimulating immunoglobulins, suggesting immune complex involvement in thyroid disorders.

    Area of Science:

    • Immunology
    • Endocrinology
    • Thyroid Research

    Background:

    • Anticomplementary activity can indicate immune complex presence.
    • Thyroid diseases often involve autoimmune processes.

    Purpose of the Study:

    • To investigate anticomplementary activity in thyroid disease patients.
    • To determine the correlation between anticomplementary activity and serum thyroglobulin levels.

    Main Methods:

    • Complement consumption (CC) assay used to measure anticomplementary activity.
    • Analysis of sera from 71 thyroid disease patients and 63 controls.
    • Correlation analysis with various antibodies and serum thyroglobulin concentrations.

    Main Results:

    • Higher anticomplementary activity observed in Graves' disease and nontoxic diffuse goiter patients compared to nontoxic goiter.

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  • Seventeen patients and one control tested positive in the CC-assay.
  • A significant correlation found between thyroid stimulating immunoglobulins and anticomplementary activity (Rho = 0.511, P < 0.05).

    • Conclusions:

    • Anticomplementary activity is present in some thyroid disease patients.
    • Thyroid stimulating immunoglobulins may exist as immune complexes in these patients.
    • No correlation found between anticomplementary activity and serum thyroglobulin or other tested antibodies.