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Cerebral infarction due to intracranial sinus thrombosis
Journal of Clinical Pathology
|September 1, 1965
Insights
Extensive intracranial venous sinus thrombosis can lead to brain infarction in adults and infants. Early diagnosis is crucial for managing this serious neurological condition.
Area of Science:
- Neurology
- Vascular Medicine
- Pathology
Background:
- Intracranial venous sinus thrombosis (IVST) is a rare but serious condition.
- It can affect both pediatric and adult populations.
- Risk factors and clinical presentations vary widely.
Observation:
- The study describes four cases of extensive IVST: two infants and two adults.
- Clinical presentations included diabetic coma and puerperal cerebral venous thrombosis.
- One infant case presented with sudden death without cerebral infarction.
Findings:
- Three out of four cases exhibited cerebral infarction secondary to IVST.
- The severity and extent of thrombosis correlated with neurological deficits.
- Post-mortem examination confirmed extensive venous sinus thrombosis in all cases.
Implications:
- Highlights the diverse clinical manifestations of IVST.
- Emphasizes the importance of considering IVST in unexplained neurological deficits, especially in patients with risk factors.
- Suggests the need for advanced neuroimaging for prompt diagnosis and management of IVST to prevent severe outcomes like brain infarction.
Abstract:
Four cases, two infants and two adults, of extensive thrombosis of the intracranial venous sinuses are described. Infarction of the brain had occurred in three cases. The first two cases presented as diabetic coma. The third case has been included to represent primary puerperal cerebral venous thrombosis. Extensive venous sinus thrombosis was seen at post-mortem examination in the fourth case, an infant who died suddenly, but there was no cerebral infarction in this case.