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[Erythematodes and nervous system (author's transl)]
Fortschritte Der Neurologie, Psychiatrie, Und Ihrer Grenzgebiete
|June 1, 1977
Summary
Lupus erythematosus frequently affects the nervous system, presenting with varied neurological and psychiatric symptoms. Differentiating lupus neurological involvement from other collagen diseases is crucial for accurate diagnosis and treatment.
Area of Science:
- Neurology
- Rheumatology
- Immunology
Context:
- Lupus erythematosus (LE) exhibits significant neurological manifestations.
- These range from peripheral and central nervous system involvement to specific syndromes like polymyositis and functional psychoses.
Purpose:
- To delineate the neurological aspects of lupus erythematosus.
- To compare and contrast LE's neurological signs with other collagen diseases such as dermatomyositis, arteritis nodosa, and progressive scleroderma.
- To highlight diagnostic challenges, including differentiation from multiple sclerosis (MS).
Summary:
- Neurological involvement in LE is common, affecting both central and peripheral systems.
- Key features include Raynaud's phenomenon, facial and eyebrow abnormalities, cerebral attacks, myopathy, and functional psychoses.
- Peripheral neuropathy is less common and subtler than in arteritis nodosa. Spinal cord involvement is typically limited and subacute.
Impact:
- Understanding these neurological facets aids in differential diagnosis, especially when LE mimics other conditions like MS.
- Early recognition of cerebral attacks (approx. 5%) necessitates careful consideration of anticonvulsant therapy.
- Neuropathological findings in LE are distinct from other inflammatory processes, supporting the 'roof-concept' of collagenosis.