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Related Experiment Videos

Autonomic hyperreflexia: intraoperative control with pentolinium tartrate.

J W Basta, K Niejadlik, V Pallares

    British Journal of Anaesthesia
    |November 1, 1977
    PubMed
    Summary

    Prophylactic use of pentolinium tartrate effectively prevented autonomic hyperreflexia (AH) in patients with spinal cord injuries during surgery. This treatment maintained near-normal blood pressure, offering a safe alternative to anesthesia.

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    Area of Science:

    • Neurology
    • Cardiology
    • Anesthesiology

    Background:

    • Autonomic hyperreflexia (AH) is a dangerous syndrome of severe hypertension.
    • AH commonly affects patients with high-level spinal cord injuries.
    • Stimulation of hollow viscera, like bladder or rectal distension, can trigger AH.

    Purpose of the Study:

    • To evaluate the protective effect of pentolinium tartrate against autonomic hyperreflexia.
    • To assess pentolinium tartrate as a prophylactic agent in patients undergoing specific surgical procedures.

    Main Methods:

    • A controlled study was conducted on unanesthetized quadriplegic and paraplegic patients.
    • Patients received prophylactic doses of pentolinium tartrate (10-15 mg).
    • The study involved surgical procedures on the rectum and bladder.

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    Main Results:

    • Pretreated patients showed significantly lower systolic and diastolic arterial pressures during surgery (P < 0.05).
    • Blood pressure remained near normal in patients who received pentolinium tartrate.
    • The control group experienced higher blood pressure levels.

    Conclusions:

    • Pentolinium tartrate is effective in preventing or controlling autonomic hyperreflexia during surgery in patients with chronic spinal cord damage.
    • This prophylactic approach offers a simple alternative to spinal or general anesthesia.
    • The findings support the use of pentolinium tartrate for managing AH in surgical settings.