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Updated: Aug 12, 2026

Murine Fetal Echocardiography
Published on: February 15, 2013
Unusual arteriovenous communications presenting as cardiac murmurs in infancy. Report of three cases
Insights
Atypical murmurs in infants may signal rare systemic arteriovenous communications, not just cardiac issues. Investigations revealed aorto-azygos fistula, vertebral arteriovenous fistula, and intercostal angioma as causes.
Area of Science:
- Pediatric Cardiology
- Vascular Surgery
- Diagnostic Imaging
Background:
- Infants presenting with thoracic murmurs are typically evaluated for cardiac abnormalities.
- Rarely, non-cardiac vascular anomalies can mimic cardiac murmurs, leading to diagnostic challenges.
Observation:
- Three infants presented with murmurs near the thorax initially suspected to be cardiac.
- Detailed investigations revealed the murmurs originated from non-cardiac vascular anomalies.
Findings:
- Case 1: Aorto-azygos fistula.
- Case 2: Vertebral arteriovenous fistula.
- Case 3: Intercostal angioma.
Implications:
- Systemic arteriovenous communications are rare but critical differential diagnoses for atypical infant murmurs.
- Consideration of these vascular lesions can prevent misdiagnosis and guide appropriate management in infants.
Abstract:
Three cases are decribed of infants presenting with murmurs in, or adjacent to, the thorax and considered to be cardiac. Later full investigations established that the murmurs were due to aorto-azygos fistula, vertebral arterio-venous fistula and intercostal angioma, respectively. While such lesions are extremely rare, the possibility of systemic arteriovenous communication should be considered in infants with atypical murmurs.
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