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A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction
14:05

A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction

Published on: December 20, 2014

Primary obstructed megaureter

P Pagano, G Passerini

    British Journal of Urology
    |November 1, 1977
    PubMed

    Insights

    Surgical intervention is essential for managing pediatric primary obstructed megaureters. While adults may benefit from conservative approaches, surgical outcomes are generally better in children than adults.

    Area of Science:

    • Urology
    • Pediatric Surgery

    Background:

    • Primary obstructed megaureter is a congenital condition affecting the ureter.
    • It can lead to significant complications if not managed appropriately.

    Purpose of the Study:

    • To report the clinical presentation and management of primary obstructed megaureters.
    • To compare treatment outcomes between children and adults.

    Main Methods:

    • Retrospective review of 46 patients (57 megaureters), 35 of whom were children.
    • Analysis of indications for surgery, preferred surgical technique (ureteric narrowing with reimplantation), and outcomes.

    Main Results:

    • Indications for surgery included pain, infection, progressive dilatation, and reduced glomerular filtration rate.
    • Children required surgical management for successful outcomes.
    • Adults could be managed conservatively in some cases.
    • Surgical results were less satisfactory in adults compared to children, potentially due to reduced ureteral elastic tissue.

    Conclusions:

    • Pediatric primary obstructed megaureters necessitate surgical intervention.
    • Conservative management may be suitable for adults.
    • The Politano-Leadbetter technique is preferred, but outcomes differ between pediatric and adult populations.

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