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Related Experiment Videos

Tumour stimulation by anti-oestrogens.

I H McIntosh, G S Thynne

    The British Journal of Surgery
    |December 1, 1977
    PubMed
    Summary

    Tumour progression occurred in two women despite anti-oestrogen therapy. This case study explores potential mechanisms behind treatment resistance to anti-oestrogen medications.

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    A correlation of erythrocyte sedimentation and plasma carcinoembryonic antigen in fibrocystic disease and carcinoma of the breast.

    Clinical oncology·1980

    Area of Science:

    • Oncology
    • Pharmacology

    Background:

    • Anti-oestrogen therapies are standard treatments for hormone-receptor-positive breast cancer.
    • Tumour resistance to anti-oestrogens can limit treatment efficacy.

    Observation:

    • Two cases of women experiencing tumour progression while on anti-oestrogen therapy were documented.
    • Clinical data and treatment histories were reviewed for these patients.

    Findings:

    • The study discusses potential biological mechanisms contributing to anti-oestrogen resistance.
    • Possible mechanisms include alterations in oestrogen receptor (ER) signalling or activation of alternative growth pathways.

    Implications:

    • Understanding these mechanisms is crucial for developing strategies to overcome anti-oestrogen resistance.
    • Further research into resistance pathways may lead to improved therapeutic options for breast cancer patients.