Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute leukaemia after busulphan.

H Stott, W Fox, D J Girling

    British Medical Journal
    |December 10, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    "Rogers" Seven-Day-Fever.

    The Indian medical gazette·2017
    Same author

    An Outbreak of Urticaria Epidemica.

    The Indian medical gazette·2017
    Same author

    On Two Varieties of Relapsing Fever Spirochætal Infection in India.

    The Indian medical gazette·2017
    Same author

    Studies in Malaria.

    The Indian medical gazette·2017
    Same author

    Studies in Malaria: Salvarsan in Malaria.

    The Indian medical gazette·2017
    Same author

    Studies in Malaria : Part II.

    The Indian medical gazette·2017
    Same journal

    Muscular pain during therapy with carbenoxolone (Biogastrone).

    British medical journal·2016
    Same journal

    ACUTE INTESTINAL OBSTRUCTION DUE TO INTRA-ABDOMINAL CAUSES.

    British medical journal·2014
    Same journal

    A CASE OF HAEMATIDROSIS.

    British medical journal·2014
    Same journal

    Incidence of ulcer in haematemesis.

    British medical journal·2011
    Same journal

    Pituitary hypothyroidism with impaired renal function.

    British medical journal·2011
    Same journal

    The fenestration operation for otosclerosis.

    British medical journal·2011
    See all related articles

    Busulphan, a chemotherapy drug, was linked to a higher risk of developing leukemia in patients with bronchial carcinoma. This risk was observed in patients who also experienced pancytopenia, suggesting busulphan

    Area of Science:

    • Oncology
    • Pharmacology
    • Hematology

    Background:

    • Lung cancer (carcinoma of the bronchus) treatment often involves chemotherapy.
    • Busulphan and cyclophosphamide are cytotoxic chemotherapy agents.
    • Long-term side effects of chemotherapy require thorough investigation.

    Purpose of the Study:

    • To evaluate the long-term effects of busulphan and cyclophosphamide.
    • To assess the leukaemogenic potential of busulphan in lung cancer patients.

    Main Methods:

    • A two-year, double-blind study involving patients who underwent surgical resection for bronchial carcinoma.
    • Patients received either busulphan, cyclophosphamide, or a placebo.
    • Long-term follow-up to monitor for adverse events, including leukemia and pancytopenia.

    Related Experiment Videos

    Main Results:

    • Four out of 243 patients treated with busulphan developed leukemia.
    • No leukemia cases were observed in the cyclophosphamide or placebo groups.
    • All four leukemia cases occurred in patients who had previously developed pancytopenia while on busulphan, 5-8 years prior to leukemia diagnosis.

    Conclusions:

    • Busulphan demonstrates leukaemogenic potential in patients treated for bronchial carcinoma.
    • The development of pancytopenia may be an early indicator of increased leukemia risk associated with busulphan.
    • Further research is needed to elucidate the mechanism of busulphan-induced leukemia.