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Effect of etomidate on intra-ocular pressure
Canadian Anaesthetists' Society Journal
|November 1, 1977
Summary
Etomidate, a short-acting hypnotic, significantly reduces intra-ocular pressure in patients aged 12-65. This effect is observed despite potential myoclonic movements, suggesting its utility in anesthesia.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Etomidate is a non-barbiturate hypnotic agent.
- Intra-ocular pressure (IOP) management is critical in certain surgical procedures.
Purpose of the Study:
- To evaluate the effect of etomidate on intra-ocular pressure.
- To determine the potential of etomidate as an anesthetic induction agent.
Main Methods:
- Administered etomidate to 40 patients (aged 12-65).
- Measured intra-ocular pressure using a Schiotz tonometer before and after etomidate injection.
Main Results:
- A significant reduction in intra-ocular pressure was observed post-etomidate administration.
- Myoclonic movements were noted as a potential side effect.
Conclusions:
- Etomidate demonstrates a hypotensive effect on intra-ocular pressure.
- The mechanism for IOP reduction requires further investigation.
- Etomidate may be a beneficial intravenous induction agent when elevated IOP is a concern.