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Related Experiment Videos

Aspirin and congenital malformations.

D Slone, V Siskind, O P Heinonen

    Lancet (London, England)
    |June 26, 1976
    PubMed
    Summary

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    This study found no increased risk of birth defects in infants whose mothers took aspirin during early pregnancy. Aspirin appears safe for use during the first trimester, suggesting it is not teratogenic.

    Area of Science:

    • Obstetrics and Gynecology
    • Pharmacology
    • Teratology

    Background:

    • Aspirin is a widely used medication during pregnancy.
    • Concerns exist regarding its potential teratogenic effects.

    Purpose of the Study:

    • To investigate the association between aspirin exposure during early pregnancy and congenital malformations.
    • To determine if aspirin is a teratogen.

    Main Methods:

    • A large cohort study of 50,282 pregnant women and their offspring in the USA.
    • Categorization of aspirin exposure into none, intermediate, and heavy.
    • Multivariate analysis to control for confounding factors.

    Main Results:

    • Malformation rates were similar across all exposure groups (no aspirin, intermediate, heavy).
    Keywords:
    AmericasAnalgesiaCardiovascular EffectsCentral Nervous System EffectsCohort AnalysisCongenital AbnormalitiesData AnalysisDeveloped CountriesDiseasesDrugsGastrointestinal EffectsIncidenceMeasurementMultivariate AnalysisNeonatal Diseases And AbnormalitiesNorth AmericaNorthern AmericaProspective StudiesResearch MethodologyStatistical StudiesStudiesTreatmentUnited StatesUrogenital Effects

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  • Observed and expected malformation numbers were comparable between groups after controlling for confounders.

    • Conclusions:

    • The study data suggest that aspirin is not teratogenic.
    • Aspirin use in the first four lunar months of pregnancy does not appear to increase the risk of congenital malformations.