Hyperbaric oxygenation: the eye as a limiting factor

In dogs exposed to 100 percent oxygen at 3 atmospheres absolute pressure for more than 4 hours, a characteristic retinal lesion, manifested as the cytoid-body change, occurs. The selectivity of this injury suggests that the eye may be used as a sensitive indicator and as a site for study of oxygen toxicity. The cytoid body, an entity of disputed genesis, was produced experimentally for the first time.