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Nasal Wipes for Influenza A Virus Detection and Isolation from Swine
05:59

Nasal Wipes for Influenza A Virus Detection and Isolation from Swine

Published on: December 4, 2015

Virulence for man of a human influenza-A virus antigenically similar to "classical" swine viruses

A S Beare, J W Craig

    Lancet (London, England)
    |July 3, 1976
    PubMed

    Insights

    A new human influenza-A strain with swine antigens caused mild infections in volunteers. This New Jersey strain showed intermediate virulence, suggesting it may not become established in humans.

    Area of Science:

    • Virology
    • Infectious Diseases
    • Public Health

    Background:

    • A novel human influenza-A strain, identified in New Jersey, U.S.A., possessed swine antigens.
    • Influenza strains with zoonotic potential require careful evaluation for human transmissibility and virulence.

    Purpose of the Study:

    • To assess the clinical effects and viral shedding of a newly isolated human influenza-A strain with swine antigens in human volunteers.
    • To determine the virulence of this novel strain in humans compared to known human and swine influenza viruses.

    Main Methods:

    • Six human volunteers were inoculated with the New Jersey influenza-A strain.
    • Clinical reactions, infection status, and viral excretion duration were monitored.

    Main Results:

    • All six volunteers became infected, experiencing mild clinical reactions.
    • Viral shedding ranged from 3 to 8 days.
    • The New Jersey strain exhibited intermediate virulence in humans, exceeding that of known swine influenza viruses.

    Conclusions:

    • The New Jersey influenza-A strain can infect humans and cause mild illness with detectable viral shedding.
    • The strain's virulence is intermediate, suggesting a potential for zoonotic transmission but not necessarily widespread human adaptation.
    • The outbreak may have been an isolated event, with limited potential for sustained human-to-human transmission.

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