Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anaphylactoid responses in rats.

G B West

    International Archives of Allergy and Applied Immunology
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Different substances induce anaphylactoid responses in rats, with activity varying by injection route. Insulin and glucose significantly affect these reactions, suggesting distinct agent classes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The stability of adrenaline solutions; storage of the proposed solution of adrenaline hydrochloride and injection of adrenaline tartrate.

    The Chemist and druggist·2010
    Same author

    The stability of adrenaline solutions; solutions of adrenaline tartrate.

    Quarterly journal of pharmacy and pharmacology·2010
    Same author

    Note on the stability of adrenaline solutions.

    The Pharmaceutical journal·2010
    Same author

    Use of potassium in the assay of curare.

    Nature·2010
    Same author

    Thrombosis of the cavernous sinus; newer concepts in its management and report of three cases.

    Journal of the American Medical Association·2010
    Same author

    Vitamin K and late tonsillar hemorrhage.

    The Laryngoscope·2010

    Area of Science:

    • Immunology
    • Pharmacology

    Background:

    • Anaphylactoid responses are acute inflammatory reactions.
    • Understanding agents that trigger these responses is crucial for research.

    Purpose of the Study:

    • To investigate the relative activities of various agents in inducing anaphylactoid responses in rats.
    • To determine the influence of injection route and metabolic modifiers (insulin, glucose) on these responses.

    Main Methods:

    • Administration of dextran, mannan, ovomucoid, carrageenan, and concanavalin A to rats via different routes (intradermal, subcutaneous).
    • Evaluation of anaphylactoid response severity.
    • Assessment of the effects of insulin pretreatment and glucose administration on the responses.

    Main Results:

    Related Experiment Videos

    • Mannan was the most potent agent, particularly via the intradermal route.
    • Dextran, mannan, and ovomucoid responses were potentiated by insulin and inhibited by glucose.
    • Carrageenan and concanavalin A were active only subcutaneously; concanavalin A responses were insulin-potentiated, while carrageenan responses were insulin-reduced.

    Conclusions:

    • At least three distinct classes of agents can induce anaphylactoid responses in rats.
    • The route of administration and metabolic state significantly modulate these responses.