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On the absorption of ascorbic acid in man.

A Kallner, D Hartmann, D Hornig

    International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition
    |January 1, 1977
    PubMed
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    This study investigated ascorbic acid (vitamin C) absorption in healthy males. Results indicate that oral vitamin C supplements are absorbed at a high rate of 80-90%.

    Area of Science:

    • Biochemistry
    • Human Physiology
    • Nutritional Science

    Background:

    • Ascorbic acid (vitamin C) is an essential nutrient with known antioxidant properties.
    • Dietary intake of vitamin C can vary significantly, impacting body levels.
    • Understanding vitamin C absorption is crucial for determining optimal supplementation strategies.

    Purpose of the Study:

    • To quantify the absorption rate of orally administered ascorbic acid in healthy adult males.
    • To assess the impact of different carrier doses on ascorbic acid absorption.
    • To measure the cumulative excretion of radiolabeled ascorbic acid over a 10-day period.

    Main Methods:

    • Seven healthy non-smoking males were placed on a restricted vitamin C diet.
    • Supplementation with 90-180 mg of ascorbic acid daily for three weeks.

    Related Experiment Videos

  • Oral administration of approximately 5 μCi of (1-14C) ascorbic acid with either 30 mg or 60 mg carrier.
  • Measurement of cumulative radioactivity in urine over 10 days following high-dose (4000 mg) daily intake.

    • Main Results:

    • The average absorption of orally administered ascorbic acid was estimated to be between 80% and 90%.
    • Radioactivity excretion in urine was monitored for 10 days after supplementation.
    • The study provides quantitative data on vitamin C bioavailability.

    Conclusions:

    • Oral supplementation with ascorbic acid demonstrates high bioavailability in healthy individuals.
    • The findings support the efficacy of oral vitamin C supplements in achieving adequate body levels.
    • Further research could explore absorption rates in different populations or under varying physiological conditions.