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Trisomy-18 and antepartal fetal distress
The Journal of Reproductive Medicine
|December 1, 1977
Insights
Cesarean sections for fetal distress and growth issues may mask severe genetic conditions like trisomy 18. Ruling out life-threatening fetal abnormalities before surgery is crucial.
Area of Science:
- Perinatology
- Medical Genetics
Background:
- Intrauterine growth retardation (IUGR) and antepartal fetal distress are common indications for cesarean section.
- Cesarean delivery is a major surgical procedure with associated risks for both mother and infant.
Observation:
- Two cases are presented where cesarean sections were performed due to IUGR and fetal distress.
- Both infants diagnosed with trisomy 18 syndrome post-delivery.
Findings:
- The combination of IUGR and fetal distress can indicate severe fetal anomalies.
- Trisomy 18 syndrome, a severe chromosomal disorder, was present in both neonates.
Implications:
- Healthcare providers should consider screening for severe fetal abnormalities before proceeding with cesarean delivery for IUGR and fetal distress.
- Early diagnosis of conditions like trisomy 18 can guide clinical decision-making and improve perinatal outcomes.
Abstract:
Two cases are presented wherein cesarean section was performed because of evidence of intrauterine growth retardation and antepartal fetal distress. Both infants had the trisomy-18 syndrome. Attention is drawn to the fact that the combination of growth retardation and fetal distress sometimes heralds the presence of severe anomalies in the fetus, and it is suggested that cesarean section should not be performed before one attempts to rule out such life-threatening abnormalities.