Neutrophil dysfunction in Crohn's disease

The migration of neutrophils into skin windows has been examined in patients with Crohn's disease and rheumatoid arthritis and compared with normal. Leucocyte migration was significantly lower in patients with Crohn's disease than in others. This abnormality of neutrophil function in Crohn's disease appears to be secondary to a defective acute inflammatory response as the neutrophils themselves were found to behave normally on in-vitro testing. A weak acute inflammatory response to particulate or antigenic material in the bowel wall could result in the chronic inflammation observed in this condition.