[Functional state of the rat liver exposed to the primary damaging action of impact G forces]

White rats were exposed to undamaging and producing the primary damage (focal hemorrhages in the lung tissue) effects of impact acceleration. Biochemical parameters of the blood characterizing the functional state of the liver parenchyma were studied. Histological and histochemical changes in this organ were also investigated. It was demonstrated that impact acceleration that induced microlesions of the lung tissue damaged the liver parenchyma as well. However, in contrast to lesions located in the lung tissue, liver damages cannot be discerned visually since they mainly involve metabolic changes. These changes are suggested by blood biochemistries indicating alteration or inhibition of specific functions of the liver: biosynthesis of cholesterol, urea, etc. Thus, a study of partial functions of the liver is a promising procedure to help evaluate possible effects of an exposure and, first of all, differentiate in vivo undamaging and damaging (pathological) effects of impact acceleration.