Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prostaglandins and the lung.

J Morley

    Postgraduate Medical Journal
    |November 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Prostaglandins (PGs) are implicated in lung inflammation and asthma. E-series PGs regulate mediator release from immune cells, offering potential for new drug development in inflammatory lung diseases.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Phase transitions in the classical simulability of open quantum systems.

    Scientific reports·2023
    Same author

    Editorial: Loneliness in Old Age: An unaddressed Health Problem.

    The journal of nutrition, health & aging·2020
    Same author

    Persistence and compliance with osteoporosis therapies among postmenopausal women in the UK Clinical Practice Research Datalink.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2019
    Same author

    Designing Drug Trials for Frailty: ICFSR Task Force 2018.

    The Journal of frailty & aging·2018
    Same author

    Implications of ICD-10 for Sarcopenia Clinical Practice and Clinical Trials: Report by the International Conference on Frailty and Sarcopenia Research Task Force.

    The Journal of frailty & aging·2018
    Same author

    Designing pharmaceutical trials for sarcopenia in frail older adults: EU/US Task Force recommendations.

    The journal of nutrition, health & aging·2013

    Area of Science:

    • Immunology
    • Pharmacology
    • Pulmonary Medicine

    Background:

    • Prostaglandins (PGs) are implicated as key mediators in the pathogenesis of asthma and chronic lung inflammation.
    • PGs exert spasmogenic effects on airways and also modulate immune cell functions.

    Purpose of the Study:

    • To highlight the role of prostaglandins, particularly E-series PGs, in regulating immune cell mediator secretion.
    • To underscore the significance of these regulatory effects in the context of asthma and chronic inflammatory lung diseases.
    • To emphasize the potential implications for drug design and evaluation.

    Main Methods:

    • Review of existing evidence on prostaglandin function in lung inflammation.
    • In vitro studies examining the regulatory effects of E-series PGs on mediator secretion.

    Related Experiment Videos

  • Analysis of the relevance of these findings to asthma and chronic inflammation.

    • Main Results:

    • Prostaglandins are confirmed mediators of asthma and chronic lung inflammation.
    • E-series PGs demonstrate potent in vitro regulatory effects on mediator secretion from basophils, mast cells, and lymphocytes.
    • These regulatory functions are significant in the context of inflammatory lung conditions.

    Conclusions:

    • E-series prostaglandins play a crucial role in regulating immune responses within the lung.
    • The modulatory effects of E-series PGs on immune cells are highly relevant for understanding and treating asthma and chronic inflammatory lung diseases.
    • Targeting these prostaglandin-mediated pathways holds promise for novel therapeutic strategies.