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Blood histamine level in bovine leukemias
Medecine Interne
|October 1, 1977
Summary
High blood histamine levels are specific to chronic myelocytic leukemia in humans, not chronic lymphocytic leukemia in cows. This finding confirms histamine as a reliable diagnostic marker for human chronic myelocytic leukemia.
Area of Science:
- Veterinary Hematology
- Oncology
- Biochemistry
Background:
- Human chronic myelocytic leukemia (CML) exhibits significantly elevated blood histamine levels (50-100 times normal).
- Previous research suggests a strong correlation between high histamine and CML in humans.
Purpose of the Study:
- To investigate blood histamine levels in cows diagnosed with chronic lymphocytic leukemia (CLL).
- To determine if elevated histamine is specific to CML or a broader indicator in leukemias.
Main Methods:
- Blood samples were collected from cows diagnosed with chronic lymphocytic leukemia.
- Histamine levels in these samples were quantified and compared to established normal ranges.
Main Results:
- Blood histamine levels in cows with chronic lymphocytic leukemia were found to be within the normal range.
- This contrasts sharply with the significantly elevated levels observed in human chronic myelocytic leukemia.
Conclusions:
- The extremely high blood histamine level is a specific characteristic of chronic myelocytic leukemia in humans.
- Histamine is a confirmed diagnostic marker for human chronic myelocytic leukemia, not a general indicator for all leukemias.