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Association of autonomous thyroid adenoma with chronic thyroiditis
Endocrinologie
|October 1, 1977
Summary
The rare coexistence of autonomous thyroid adenoma (ATA) and chronic thyroiditis suggests a complex origin. This association may stem from initial thyrotropin deficiency leading to hyperplasia, later becoming autonomous.
Area of Science:
- Endocrinology
- Thyroidology
- Pathology
Background:
- Coexistence of autonomous thyroid adenoma (ATA) and chronic thyroiditis is rare.
- This association suggests complex pathogeny involving nodular autonomy and immune disorders.
- Limited data exists on this specific co-occurrence.
Purpose of the Study:
- To investigate the pathogeny of autonomous thyroid adenoma coexisting with chronic thyroiditis.
- To present cases illustrating this rare clinical association.
- To explore the potential role of thyrotropin deficiency in its development.
Main Methods:
- Retrospective analysis of 71 thyroidectomized ATA cases.
- Identification and detailed review of cases with coexisting chronic thyroiditis.
- Clinical and pathological data evaluation.
Main Results:
- Four cases of ATA associated with chronic thyroiditis were identified within a series of 71 ATA cases.
- Radioiodine accumulation was observed solely at the adenoma level in euthyroid patients.
- The findings support a hypothesis involving initial thyrotropin deficiency and subsequent autonomous hyperfunction.
Conclusions:
- The association of ATA with chronic thyroiditis supports a complex pathogeny.
- A proposed mechanism involves initial TSH-dependent thyroiditis followed by TSH secretion depression, leading to localized hyperplasia that becomes autonomous.
- This supports the hypothesis of an initial thyreotropic deficiency in the development of ATA with chronic thyroiditis.