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Effect of heparin on the substrate utilization during prolonged exercise.
Scandinavian Journal of Clinical and Laboratory Investigation
|November 1, 1977
Summary
Heparin increased free fatty acid (FFA) uptake in exercising legs during exercise. However, it did not affect leg glucose uptake or splanchnic glucose production, suggesting FFA
Area of Science:
- Exercise Physiology
- Metabolic Regulation
- Human Physiology
Background:
- Free fatty acids (FFA) and glucose are primary substrates during exercise.
- Heparin is known to affect lipid metabolism.
- Understanding substrate utilization during exercise is crucial for performance and health.
Purpose of the Study:
- To investigate the effect of heparin on leg and splanchnic exchange of FFA and glucose during exercise.
- To compare substrate utilization with and without prior heparin administration.
Main Methods:
- Six healthy males performed 90-minute bicycle exercise.
- Measurements included leg and splanchnic FFA and glucose exchange.
- Data were compared to a previous study without heparin.
Main Results:
- Heparin administration elevated resting plasma FFA but not during exercise.
- FFA uptake in exercising legs was augmented post-heparin due to increased fractional uptake.
- Leg glucose uptake and splanchnic glucose production remained unaffected by heparin.
Conclusions:
- Inhibition of glucose uptake by elevated FFA is likely of minor importance in regulating muscle substrate use during human exercise.
- Heparin enhances FFA utilization in exercising muscles.
- Further research may explore specific mechanisms of FFA uptake regulation.