Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement system studies in adult coeliac disease.

P Teisberg, O Fausa, K Baklien

    Scandinavian Journal of Gastroenterology
    |January 1, 1977
    PubMed
    Summary

    Adult coeliac disease involves complement system activation, particularly the classical pathway, linked to gluten intake. Dietary gluten reduction significantly lowers complement activation products in these patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Physical workload in neck, shoulders and wrists/hands in dental hygienists during a work-day.

    Applied ergonomics·2012
    Same author

    Familial adenomatous polyposis: mental health, psychosocial functioning and reactions to genetic risk in adolescents.

    Clinical genetics·2010
    Same author

    Relationship between Fecal Content of Fatty Acids and Cyclooxygenase mRNA Expression and Fatty Acid Composition in Duodenal Biopsies, Serum Lipoproteins, and Dietary Fat in Colectomized Familial Adenomatous Polyposis Patients.

    Journal of nutrition and metabolism·2010
    Same author

    Carbon dioxide insufflation in colonoscopy: safe and effective in sedated patients.

    Endoscopy·2005
    Same author

    Duodenal adenomatosis in familial adenomatous polyposis.

    Gut·2004
    Same author

    Cholangiocarcinoma in primary sclerosing cholangitis: risk factors and clinical presentation.

    Scandinavian journal of gastroenterology·2002

    Area of Science:

    • Immunology
    • Gastroenterology
    • Complement System Biology

    Background:

    • Coeliac disease is an autoimmune disorder triggered by gluten ingestion.
    • The role of the complement system in coeliac disease pathogenesis is not fully understood.

    Purpose of the Study:

    • To investigate complement system activation in adult coeliac disease patients.
    • To determine the association between gluten ingestion and complement activity.

    Main Methods:

    • Studied complement activation products (C3, Factor B) and levels (C4, C3) in 22 adult coeliac disease patients.
    • Compared findings in untreated patients and those on a gluten-free diet.

    Main Results:

    • All untreated patients showed C3 activation products; 4 had alternate pathway factor B activation.
    • Lowered C4 and C3 levels were observed, with C4 depression being statistically significant.
    • Circulating C3 activation products decreased significantly on a gluten-free diet.

    Conclusions:

    • Evidence suggests classical pathway complement activation in adult coeliac disease.
    • Gluten ingestion is associated with increased complement activity.
    • Complement activation by a humoral immune response to gluten may contribute to intestinal tissue injury.

    Related Experiment Videos