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Influence of the lethal yellow (Ay) gene on estrous synchrony in mice
Science (New York, N.Y.)
|July 1, 1966
Abstract:
Introduction of an adult male induces partially synchronous estrus in female laboratory mice that have been caged in groups. In the inbred YS/ChWf strain, this effect was observed only when the male was nonyellow (aa), while males heterozygous for the lethal yellow allele (A(y)a) failed to induce synchrony.
Insights
Introducing a nonyellow male mouse can trigger synchronized estrus in grouped female mice. However, males with the lethal yellow allele did not cause this reproductive synchrony.
Area of Science:
- Animal behavior
- Reproductive biology
- Genetics
Background:
- Group-housed female mice exhibit estrus synchronization when exposed to novel adult males.
- The genetic background of the male mouse may influence this pheromonally mediated effect.
Purpose of the Study:
- To investigate the role of the lethal yellow (A(y)) allele in male-induced estrus synchronization in YS/ChWf inbred mice.
Main Methods:
- Exposure of group-housed female mice to either nonyellow (aa) or heterozygous (A(y)a) adult males.
- Observation and recording of estrus timing in female mice.
Main Results:
- Estrus synchronization was observed in females exposed to nonyellow (aa) males.
- Females exposed to males heterozygous for the lethal yellow allele (A(y)a) did not show significant estrus synchronization.
Conclusions:
- The presence of the lethal yellow allele (A(y)) in males prevents the induction of estrus synchronization in this mouse strain.
- Male coat color genetics, specifically the A(y) allele, plays a crucial role in modulating pheromonal communication influencing female reproductive cycles.