Erythrocytic glucose-6-phosphate dehydrogenase deficiency amongst non tribal population of Orissa

Area of Science:

• Genetics
• Biochemistry
• Hematology

Background:

• Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is a common inherited red blood cell disorder.
• Understanding its prevalence is crucial for public health management and clinical practice.

Purpose of the Study:

• To determine the prevalence of G-6-PD deficiency in the non-tribal population of Orissa, India.
• To characterize the expression levels of G-6-PD deficiency.

Main Methods:

• Blood samples from 300 non-tribal subjects in Orissa were analyzed.
• The methaemoglobin reduction test was employed to screen for G-6-PD deficiency.

Main Results:

• G-6-PD deficiency was detected in 19 individuals (6.3% prevalence).
• Full expression of the deficiency was observed in 11 subjects (3.6%), and partial expression in 8 subjects (2.6%).
• A higher incidence was noted in males, but the difference was not statistically significant.

Conclusions:

• The study establishes a baseline prevalence of G-6-PD deficiency in the studied population.
• Findings contribute to the understanding of G-6-PD deficiency distribution in India.
• Further research into genetic factors and clinical implications is warranted.