[Methylcholanthrene sensitization in skin tumor induction]

Injection of 2 mg of methylcholanthrene renders a sensitizing effect on separate tissues and enhances the development of skin papillomas and cancer in skin application of methylcholanthrene. To the time of papillomas appearance sensitized animals showed immunosuppression being more significant than in nonsensitized mice. Animals with cancerous tumors, both sensitized and non-sensitized, showed paralysis of immunological mechanisms of the organism protection.