[Studies of human serum and lung-tissue oxacillin levels]

After the intramuscular administration of 500 mg oxacillin (oxacillin-chinoin) the serum level and the level of the pulmonary tissue of 15 patients operated on account of different diseases of the respiratory tract were determined by means of the agar diffusion method. In the first hour the serum level showed the average value of 11.8 mcg/ml, the level of the pulmonary tissue was 2.4 mcg/g. 60-120 minutes after the administration the serum level rapidly diminished, the decrease of the level of the pulmonary tissue was smaller, i.e. oxacillin was more rapidly excreted from the serum than from the pulmonary tissue. Taking into consideration the minimum inhibition concentration of oxacillin on the basis of our results we are of the opinion that oxacillin is suitable for the treatment of gram-positive oxacillin-sensitive infections of the lungs.