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Related Experiment Videos

Interspike interval fluctuations in the crayfish stretch receptor.

D R Firth

    Biophysical Journal
    |March 1, 1966
    PubMed
    Summary
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    Nerve impulse trains from crayfish stretch receptors exhibit remarkable regularity. Fluctuations are too small to be explained by shot or Johnson noise, suggesting other membrane noise sources are at play.

    Area of Science:

    • Neuroscience
    • Biophysics
    • Sensory Physiology

    Background:

    • Nerve impulse trains, particularly from sensory receptors, are crucial for transmitting biological information.
    • The regularity of these impulse trains is a key characteristic influencing signal fidelity.
    • Understanding the sources of variability in nerve impulse timing is essential for deciphering neural coding.

    Purpose of the Study:

    • To quantify the regularity of nerve impulse trains from the crayfish stretch receptor under steady conditions.
    • To investigate the sources of interval fluctuations in these nerve impulses.
    • To evaluate the contributions of known noise sources like shot noise and Johnson noise.

    Main Methods:

    • Utilizing experimental techniques to record and measure intervals of nerve impulses from crayfish stretch receptors.

    Related Experiment Videos

  • Employing mathematical analysis to assess the regularity and identify serial correlations in impulse timing.
  • Evaluating theoretical contributions of shot noise and Johnson noise in a long axon model.

    • Main Results:

    • Nerve impulse trains demonstrated high regularity, with a standard deviation of 0.7 x 10(-2)tau for mean intervals (tau) between 15-80 msec.
    • A serial correlation coefficient of approximately -0.2 was observed for tau values between 35-70 msec.
    • Both shot noise and Johnson noise were found to be comparable in magnitude but insufficient to solely explain the observed interval fluctuations.

    Conclusions:

    • The extreme regularity of crayfish stretch receptor nerve impulses suggests sophisticated intrinsic mechanisms.
    • Observed interval fluctuations are not adequately explained by standard shot or Johnson noise models.
    • Further investigation into other forms of membrane noise is warranted to fully account for impulse train variability.