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Related Experiment Videos

Effect of large-dose ascorbic acid on the two-drop clinitest determination.

D Smith, W W Young

    American Journal of Hospital Pharmacy
    |December 1, 1977
    PubMed
    Summary

    High doses of ascorbic acid (vitamin C) do not affect the two-drop Clinitest for detecting urinary glucose in normal individuals. This study challenges previous literature suggesting potential false positive results.

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    Area of Science:

    • Biochemistry
    • Clinical Chemistry
    • Pharmacology

    Background:

    • Ascorbic acid, or vitamin C, is commonly consumed in high doses.
    • Secondary literature suggests high doses of ascorbic acid may interfere with laboratory tests, potentially causing false positives.
    • The two-drop Clinitest is a method used to detect glucosuria (glucose in urine).

    Purpose of the Study:

    • To investigate the effect of high-dose ascorbic acid intake on the accuracy of the two-drop Clinitest for determining glucosuria.
    • To evaluate whether renal excretion of ascorbic acid or its metabolites impacts Clinitest results in normal individuals.

    Main Methods:

    • Nine healthy individuals participated in the study.
    • Participants received three-gram and nine-gram doses of ascorbic acid daily for seven days, following once-daily and three-times-daily schedules.
    • A total of 748 two-drop Clinitest determinations were performed.

    Main Results:

    • Only two trace positive Clinitest results (0.27%) were observed out of 748 tests.
    • These results indicate no significant impact of high-dose ascorbic acid on the two-drop Clinitest for glucosuria detection.

    Conclusions:

    • High-dose ascorbic acid intake does not appear to cause false positive results in the two-drop Clinitest for urinary glucose determination in normal individuals.
    • This study highlights the importance of critically evaluating secondary literature regarding drug-laboratory test interferences.

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