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Related Experiment Videos

Glottic squamous cell carcinoma (T(2)): a retrospective study.

P J Doyle, A Flores, D R Bell

    The Annals of Otology, Rhinology, and Laryngology
    |November 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

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    Cobalt radiotherapy is an effective primary treatment for T(2) glottic squamous cell carcinoma, with salvage surgery improving outcomes for recurrent cases. This approach offers a high five-year survival rate for patients with this laryngeal cancer.

    Area of Science:

    • Oncology
    • Radiotherapy
    • Laryngeal Cancer Research

    Background:

    • Glottic squamous cell carcinoma (SCC) is a significant cause of laryngeal cancer.
    • T(2) stage indicates a specific tumor size and location within the larynx.
    • Historically, treatment options for laryngeal SCC have evolved.

    Purpose of the Study:

    • To evaluate the long-term efficacy of cobalt radiotherapy as a primary treatment for T(2) glottic squamous cell carcinoma.
    • To assess the role and success rate of salvage surgery following radiotherapy for recurrent disease.
    • To determine the overall survival and disease-free survival rates in patients treated with this combined approach.

    Main Methods:

    • Retrospective analysis of 73 patients diagnosed with T(2) glottic SCC between 1960 and 1972.

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  • Primary treatment involved a full course of cobalt radiotherapy.
  • Follow-up included assessment for recurrence, salvage surgery, and long-term survival outcomes (minimum five years).

    • Main Results:

    • Only 9.6% of patients died from or with recurrent laryngeal carcinoma.
    • 14 patients experienced recurrence, with 12 undergoing salvage surgery.
    • Salvage surgery successfully controlled recurrence in 7 of 12 patients, with 3 remaining disease-free.
    • 57.5% of patients were alive and disease-free at five years or more post-diagnosis.

    Conclusions:

    • A full course of cobalt radiotherapy is a highly effective primary treatment for T(2) glottic squamous cell carcinoma.
    • Salvage surgery is a valuable option for managing radiotherapy-induced recurrences.
    • The combination of radiotherapy followed by selective salvage surgery offers favorable long-term outcomes for T(2) glottic SCC.