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[Penetration of polyene antibiotics into human embryonic kidney tissue cell cultures]
Antibiotiki
|December 1, 1977
Abstract:
Penetration of 14C-amphotericin AM-2 into the cells of the tissue culture of the human embryon kidneys was studied by means of light autoradiography after incubation with the antibiotic. Microscopic examination of the autographs of the cell slices revealed the presence of the radioactive label in the cytoplasm and nucleoplasm of the cells. The revealed intracellular localization of the label was evident of the antibiotic penetration into the cells.
Insights
This study shows that the antifungal drug amphotericin AM-2 penetrates human kidney cells. The radioactive label was found within the cell
Area of Science:
- Cell Biology
- Pharmacology
- Mycology