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Related Experiment Videos

Cardiovascular response to increasing theophylline concentrations.

R I Ogilvie, P G Fernandez, F Winsberg

    European Journal of Clinical Pharmacology
    |December 28, 1977
    PubMed
    Summary

    Theophylline increases forearm blood flow and venous distensibility, with heart rate changes at higher doses. Circulatory responses varied significantly among individuals, despite consistent plasma concentrations.

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    Area of Science:

    • Pharmacology
    • Cardiovascular Physiology

    Background:

    • Theophylline is a widely used medication with known cardiovascular effects.
    • Understanding the precise circulatory impact of theophylline is crucial for safe and effective therapeutic use.

    Purpose of the Study:

    • To investigate the circulatory effects of plateau plasma theophylline concentrations.
    • To assess changes in systemic and regional hemodynamics in response to theophylline.

    Main Methods:

    • Utilized forearm plethysmography, systolic time intervals, and echocardiography in healthy male volunteers.
    • Measured systemic arterial and forearm venous pressures, forearm blood flow, and venous distensibility.
    • Monitored heart rate, left ventricular ejection time index, and isovolumetric contraction time.

    Main Results:

    • Theophylline significantly increased forearm blood flow (up to 41.2%) and venous distensibility (up to 20.9%) in a dose-dependent manner.
    • Heart rate and systolic time intervals showed changes at higher theophylline concentrations (10-20 mg/l), indicating altered cardiac function.
    • Significant interindividual variability in circulatory responses was observed, with no consistent changes in stroke volume or ejection fraction.

    Conclusions:

    • Theophylline exerts dose-dependent vasodilatory effects on the forearm vasculature.
    • Cardiac responses to theophylline are variable and may be influenced by factors beyond plasma concentration.
    • Further research is needed to elucidate the mechanisms behind the interindividual variability in theophylline's cardiovascular effects.

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