Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methylphenidate, amygdalectomy, and active avoidance performance in the rat.

L T Yeudall, R E Walley

    Journal of Comparative and Physiological Psychology
    |December 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Factor Analytic Studies Of Human Brain Damage: I. First And Second-Order Factors And Their Brain Correlates.

    Multivariate behavioral research·2016
    Same author

    FACTORS OF EMOTIONALITY RELATED TO ALCOHOL CONSUMPTION IN LABORATORY MICE.

    Multivariate behavioral research·2016
    Same author

    Sadism and other paraphilias in normal controls and aggressive and nonaggressive sex offenders.

    Archives of sexual behavior·1992
    Same author

    Neurophysiological and neuropsychological study of two cases of multiple personality syndrome and comparison with chronic hysteria.

    International journal of psychophysiology : official journal of the International Organization of Psychophysiology·1990
    Same author

    Early interference in a priming task with brief masked targets.

    Canadian journal of psychology·1989
    Same author

    Effect of low-intensity hippocampal stimulation on spatial versus working memory in rats.

    Behavioral neuroscience·1988

    Amygdalectomy impairs active avoidance learning in rats, but methylphenidate administration significantly improves performance and retention. This suggests methylphenidate

    Area of Science:

    • Neuroscience
    • Behavioral Neuroscience
    • Psychopharmacology

    Background:

    • Amygdalectomy, the surgical removal of the amygdala, is known to impair the performance of active avoidance responses.
    • Methylphenidate is a central nervous system stimulant that primarily acts on dopaminergic pathways.

    Purpose of the Study:

    • To investigate the effects of methylphenidate on active avoidance learning and retention in amygdalectomized rats.
    • To explore the potential role of dopaminergic mechanisms in the observed effects.

    Main Methods:

    • Rats underwent amygdalectomy or served as controls.
    • Animals were trained on an active avoidance task in a shuttle box.
    • Methylphenidate was administered at varying doses to control animals and to amygdalectomized animals during the latter half of training.

    Related Experiment Videos

    Main Results:

    • Amygdalectomized rats showed impaired performance in active avoidance tasks.
    • Methylphenidate administration led to a significant improvement in performance in amygdalectomized rats.
    • Retention of the avoidance response was observed in amygdalectomized rats treated with methylphenidate.

    Conclusions:

    • Amygdalectomy impairs, but does not prevent, the learning and retention of active avoidance responses.
    • Methylphenidate can enhance performance and retention in amygdalectomized rats, suggesting a modulation of underlying neural mechanisms.
    • The findings highlight the complex interplay between the amygdala, methylphenidate, and avoidance learning, potentially involving dopaminergic systems.