[Absorption and metabolism of 14C-noradrenaline in the ischemic rabbit kidney]

Absorption (capture) and metabolism of exogenous 14C-noradrenalin (14C-NA) by the renal tissue were studied in rabbits with artificially induced ischemia of the kidney and in control normotensive animals subjected to sham operation. We treated the tissue by our modification of the methods suggested by Whytly at al. (1961) and Kopin et al. (1961). The experiments were conducted on 49 chinchilla rabbits. The experimental and control animals were killed in groups, 1,4, and 8 weeks after the operation. The results obtained were expressed in percentage of the administered radioactivity dose per 200 mg of tissue. It was determined that the degree of 14C-NA capture by an ischemic kidney decreased in the 1st and was restored in the 4th and 8th postoperative weeks. At the same time, the production of 14C-normetanephrine- and 14C-vanillylamygdalic acid in the ischemic kidney was delayed; the amount of unchanged 14C-NA and 14C-dihydroxyamygdalic acid increased. The absorption and metabolism of 14C-NA in intact (nonischemic) kidneys did not differ essentially from those in the kidneys of the control animals.