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Lactulose in vincristine-induced constipation.

A C Harris, J M Jackson

    The Medical Journal of Australia
    |October 22, 1977
    PubMed
    Summary

    Lactulose effectively treats severe constipation caused by vincristine chemotherapy. This simple treatment improves patient quality of life without significant side effects.

    Area of Science:

    • Oncology
    • Gastroenterology
    • Pharmacology

    Background:

    • Vincristine is a chemotherapy agent known to cause refractory constipation.
    • Managing vincristine-induced constipation is crucial for patient comfort and treatment adherence.

    Purpose of the Study:

    • To evaluate the efficacy of lactulose in treating vincristine-induced constipation.
    • To assess lactulose as a prophylactic agent for this side effect.

    Main Methods:

    • A case series involving six patients with refractory vincristine-induced constipation.
    • Two patients received lactulose for prophylaxis.
    • Lactulose dosage up to 25 ml thrice daily was administered.

    Main Results:

    • Lactulose demonstrated effectiveness in treating refractory constipation in six patients.

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  • Lactulose was successful in preventing constipation in two prophylactic cases.
  • The treatment was well-tolerated with no serious adverse effects.

    • Conclusions:

    • Lactulose is a simple, effective, and safe option for managing vincristine-induced constipation.
    • Lactulose can significantly improve the quality of life for cancer patients undergoing vincristine therapy.