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Substance P in rat brain synaptosomes.

F Lembeck, N Mayer, G Schindler

    Naunyn-Schmiedeberg'S Archives of Pharmacology
    |December 1, 1977
    PubMed
    Summary
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    Rat synaptosomes release substance P (SP) when stimulated. This release is calcium-dependent and SP can be synthesized and stored within synaptosomes.

    Area of Science:

    • Neuroscience
    • Biochemistry

    Background:

    • Substance P (SP) is a neuropeptide involved in neurotransmission.
    • Understanding SP release mechanisms is crucial for neurological research.

    Purpose of the Study:

    • To investigate the conditions governing the release and synthesis of Substance P (SP) in rat brain synaptosomes.

    Main Methods:

    • Incubation of rat brain synaptosomes under varying conditions (temperature, ionic composition).
    • Stimulation using potassium ions and electrical fields.
    • Measurement of SP content within synaptosomes.

    Main Results:

    • Potassium ions and electrical stimulation induced SP release.
    • High potassium-induced SP release was calcium-dependent.

    Related Experiment Videos

  • SP was retained in sucrose but showed dynamic changes at 30°C, indicating synthesis and potential storage.

    • Conclusions:

    • Synaptosomes synthesize and store Substance P.
    • SP release is triggered by depolarization and is calcium-dependent.
    • Phosphatidyl serine may be involved in SP storage before release.