[Reactions and damage following external influence of drugs and occupational noxae on the skin]

Changes of the skin by the external influence of drugs and occupational substances are to be divided up into direct toxical influences, deposits, pharmacodynamical effects and immunologically directed reactions. With easily penetrating substances serious general effects like the formation of methaemoglobin and the intoxication with mercury have been observed. Development, diagnostic, prophylaxis and therapy of the cellular immunological reaction are thoroughly set forth.