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Pneumococcal antibodies in maxillary sinus secretion.

C Carenfelt

    Scandinavian Journal of Infectious Diseases
    |January 1, 1977
    PubMed
    Summary
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    Local antibodies, particularly Immunoglobulin A (IgA), are key for fighting mucosal infections like pneumococcal maxillary sinusitis. Their presence in sinus secretions, not serum, suggests local immune responses are crucial for recovery.

    Area of Science:

    • Immunology
    • Infectious Diseases
    • Otolaryngology

    Background:

    • Mucosal infections' resistance and recovery may depend more on local antibodies than serum antibodies.
    • Pneumococcal infections, such as maxillary sinusitis, are common and can lead to significant morbidity.

    Purpose of the Study:

    • To investigate the role of local antibodies in patients with pneumococcal maxillary sinusitis.
    • To compare the levels of IgA, IgG, and IgM antibodies in sinus secretions and serum.

    Main Methods:

    • Quantified IgA, IgG, and IgM antibodies against isolated pneumococci in sinus secretions and serum from 14 patients.
    • Utilized the indirect immunofluorescence technique for antibody quantification.

    Main Results:

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    • Type-specific pneumococcal antibodies were predominantly found in sinus secretions, mainly of the IgA class.
    • A frequent absence of type-specific IgA antibodies in serum suggested local synthesis.
    • In 5 patients, drainage of purulent sinus secretion was followed by a local increase in antibodies.

    Conclusions:

    • Local synthesis of IgA antibodies in sinus secretions plays a significant role in combating pneumococcal maxillary sinusitis.
    • The presence and local increase of antibodies in sinus secretions are important indicators of resistance and recovery from mucosal infections.