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The effect of propranolol on normal physiologic tremor
Electroencephalography and Clinical Neurophysiology
|September 1, 1976
Summary
Intravenous propranolol significantly reduces physiological tremor by 34-60%. This effect, observed with small doses, shows a linear relationship with baseline tremor size after a 10-minute delay.
Area of Science:
- Pharmacology
- Neuroscience
- Physiology
Background:
- Physiological tremor is a normal bodily function.
- Propranolol is a beta-blocker medication.
- The central nervous system's role in tremor is complex.
Purpose of the Study:
- To investigate the effect of intravenous propranolol on normal physiological tremor.
- To determine the dose-response relationship and onset of action.
Main Methods:
- Administration of intravenous propranolol.
- Measurement of physiological tremor before and after drug administration.
- Analysis of tremor reduction in relation to propranolol dosage and baseline tremor levels.
Main Results:
- Intravenous propranolol caused a 34-60% decrease in physiological tremor.
- The reduction was dose-dependent, with smaller doses (<12 mug/kg) showing a linear correlation with baseline tremor size.
- A 10-minute delay was observed before the tremor-reducing effect became apparent.
Conclusions:
- Propranolol effectively reduces physiological tremor.
- The findings suggest a potential role for a centrally acting metabolite of propranolol in mediating this effect.
- Further research into the specific metabolite and its mechanism of action is warranted.