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Related Experiment Videos

Androgen of the human prostate.

W E Farnsworth, J R Brown

    Endocrine Research Communications
    |January 1, 1976
    PubMed
    Summary

    Prostate cancer tissue shows higher testosterone and its metabolites than benign tissue, despite lower free testosterone in the blood. Dihydrotestosterone (DHT) is the primary androgen in prostate tissue.

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    Area of Science:

    • Endocrinology
    • Urology
    • Oncology

    Background:

    • Testosterone (T) and its metabolites play crucial roles in prostate physiology and pathology.
    • Understanding androgen levels in benign prostatic hyperplasia (BPH) and prostate cancer (PCa) is vital for treatment strategies.

    Purpose of the Study:

    • To investigate the relationship between plasma androgen concentrations and intraprostatic levels of testosterone (T), dihydrotestosterone (DHT), and 5 alpha-androstan-3-alpha, 17 beta-diol (DIOL).
    • To compare androgen concentrations in benign hypertrophic prostate (BHP) and carcinomatous prostate (PCa) tissues.

    Main Methods:

    • Measurement of total and apparent free testosterone in plasma.
    • Quantification of T, DHT, and DIOL concentrations in prostate tissue samples from patients with BHP and PCa.
    • Comparative analysis of androgen levels between plasma and tissue, and between BHP and PCa tissues.

    Main Results:

    • Intraprostatic androgen concentrations were approximately fourfold higher than in plasma, independent of plasma levels.
    • Dihydrotestosterone (DHT) constituted about 75% of the total androgen content within prostate tissue.
    • Prostate cancer tissue exhibited 29% higher levels of T and its metabolites compared to benign hypertrophic prostate tissue, despite lower apparent free testosterone in the plasma.

    Conclusions:

    • Prostate cancer is characterized by elevated levels of testosterone and its metabolites, particularly DHT, within the tissue.
    • Local androgen metabolism and accumulation in the prostate, rather than circulating levels, may be more significant in prostate cancer development.
    • Further research into tissue-specific androgen dynamics is warranted for improved understanding and therapeutic targeting of prostate cancer.

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